Dr. Jean-Pierre Simorre
Research Director at Institute de Biology Structurale, CNRS
For more than 10 years, I have been working on the theme of antibiotic resistance, which seems to me to be an important issue for society. I have established numerous collaborations with teams at the forefront of microbiology in order to answer relevant questions in microbiology and to make the best use of the most efficient biophysical methods.
Working in the BREAKthrough partnership, which brings together teams at the forefront of research, is a very motivating prospect for me.
Jean-Pierre Simorre is CNRS Research Director in the Biomolecular NMR Spectroscopy Group at IBS, director of the French Research Infrastructure for Nuclear Magnetic Resonance at very High Fields and Deputy of Large research infrastructures, Chemistry Institute, CNRS. He is an author of 113 Publications.
Jean-Pierre Simorre has established international reputation in the structural and dynamical study of proteins involved in the morphogenesis of the bacterial cell wall by NMR. He has resolved the structure of different proteins involved in PG morphogenesis by liquid sate NMR, developed new approaches to study the structure and the flexibility of the intact cell wall by solid state NMR, characterized molecular interactions at the bacterial cell surface.
- Outer-membrane lipoprotein LpoB spans the periplasm to stimulate the peptidoglycan synthase PBP1B. Egan AJ, Jean NL, Koumoutsi A, Bougault CM, Biboy J, Sassine J, Solovyova AS, Breukink E, Typas A, Vollmer W, Simorre JP. Proc Natl Acad Sci U S A. 2014 Jun 3;111(22):8197-202. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4050580/pdf/pnas.201400376.pdf
- Dynamics induced by β-lactam antibiotics in the active site of Bacillus subtilis L,D-transpeptidase. Lecoq L, Bougault C, Hugonnet JE, Veckerlé C, Pessey O, Arthur M, Simorre JP. Structure. 2012 May 9;20(5):850-61. https://www.sciencedirect.com/science/article/pii/S0969212612001323
- Structure of Enterococcus faecium l,d-transpeptidase acylated by ertapenem provides insight into the inactivation mechanism. Lecoq L, Dubée V, Triboulet S, Bougault C, Hugonnet JE, Arthur M, Simorre JP.ACS Chem Biol. 2013;8(6):1140. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4013547/pdf/nihms468063.pdf
- Structure-function analysis of the extracellular domain of the pneumococcal cell division site positioning protein MapZ. Manuse S, Jean NL, Guinot M, Lavergne JP, Laguri C, Bougault CM, VanNieuwenhze MS, Grangeasse C, Simorre JP. Nat Commun. 2016 Jun 27;7:12071. https://www.nature.com/articles/ncomms12071
- Dynamics characterization of fully hydrated bacterial cell walls by solid-state NMR: evidence for cooperative binding of metal ions. Kern T, Giffard M, Hediger S, Amoroso A, Giustini C, Bui NK, Joris B, Bougault C, Vollmer W, Simorre JP. J Am Chem Soc. 2010 Aug 11;132(31):10911-9. https://pubs.acs.org/doi/10.1021/ja104533w
- Atomic model of a cell-wall cross-linking enzyme in complex with an intact bacterial peptidoglycan. Schanda P, Triboulet S, Laguri C, Bougault CM, Ayala I, Callon M, Arthur M, Simorre JP. J Am Chem Soc. 2014 Dec 24;136(51):17852-60. doi:10.1021/ja5105987. https://pubs.acs.org/doi/10.1021/ja5105987
- Solid State NMR Studies of Intact Lipopolysaccharide Endotoxin. Laguri C, Silipo A, Martorana AM, Schanda P, Marchetti R, Polissi A, Molinaro A, Simorre JP. ACS Chem Biol. 2018 Aug 17;13(8):2106-2113. https://pubs.acs.org/doi/abs/10.1021/acschembio.8b00271
