Dr. Margherita Sosio

I hold a degree in Agricultural Sciences from the University of Milan (my first loves were plants and flowers) and conducted my postdoctoral research at ETH, Zurich (plants and flowers were betrayed by microorganisms).

Before joining Naicons in 2007, I held positions as research scientist in different pharma companies including Biosearch Italia-Vicuron in Gerenzano (Italy), where I held various positions with increasing responsibility over my 20-year tenure. 

I really enjoy working with passionate and promising young scientists with many ideas and an almost endless desire to learn (although sometimes I have to dampen their enthusiasm).

Margherita Sosio is co-founder of and Microbiology Director at Naicons Srl. Her expertise lies in microbial genetic and molecular biology, in particular in the genetics of antibiotic producers, including identification and characterization of antibiotic biosynthetic and resistance genes, in the screening of natural product for antimicrobial activity, and in the characterisation and development of antibiotics.

Margherita is the coordinator of the EU-funded project ‘LAntibiotic Production: Technology, Optimization and improved Process’ (FP7-KBBE-2009-3, 2010-2013, grant no. 245066).

She supervises Early-Stage Researchers (ESRs) in the following projects: TRAIN Asap, FP7 for research, technological development and demonstration, GA 289285; Train2Target, H2020-MSCA-ITN-2016, 2017-2020GA no. 721484; INNOTARGETS, GA no. 956154, H2020-MSCA-ITN-2020, 2021-2024. Principal Investigator in the project H2020-BG-2014-2, NOMORFILM, GA. No. 634588, BG-03-2014; Novel marine biomolecules against biofilm.

Margherita has co-authored over 90 scientific papers and seven patent applications in the field of antibiotics.

  • Musiol-Kroll EM, Tocchetti A, Sosio M, Stegmann E. “Challenges and advances in genetic manipulation of filamentous actinomycetes – the remarkable producers of specialized metabolites”. Nat Prod Rep. 2019 Sep 1;36(9):1351-1369.


  • Alduina R, Tocchetti A, Costa S, Ferraro C, Cancemi P, Sosio M, Donadio S. “A Two-Component regulatory system with opposite effects on glycopeptide antibiotic biosynthesis and resistance”. Sci Rep. 2020 Apr 10;10(1):6200.


  • Zdouc MM, Alanjary MM, Zarazúa GS, Maffioli SI, Crüsemann M, Medema MH, Donadio S, Sosio M. “A biaryl-linked tripeptide from Planomonospora reveals a widespread class of minimal RiPP gene clusters”. Cell Chem Biol. 2020 Dec 10: S2451-9456(20)30472-4.


  • Zdouc MM, Iorio M, Maffioli SI, Crüsemann M, Donadio S, Sosio M. “Planomonospora: A Metabolomics Perspective on an Underexplored Actinobacteria Genus”. J Nat Prod. 2021 Feb 26;84(2):204-219.


  • Schorn MA, Verhoeven S, Ridder L, et al. “A community resource for paired genomic and metabolomic data mining”. Nat Chem Biol. 2021. Apr 17:363-368.


  • Iorio M, Gentile A, Brunati C, Tocchetti A, Landini P, Maffioli SI, Donadio S, Sosio M. “Allopeptimicins: unique antibacterial metabolites generated by hybrid PKS-NRPS, with original self-defense mechanism in Actinoallomurus”. RSC Adv. 2022 Jun 6;12(26):16640-16655.


  • Del Carratore F, Iorio M, Pérez-Bonilla M, Schmidt K, Pérez-Redondo R, Sosio M, Macdonald SJ, Gyulev IS, Tsigkinopoulou A, Thomas GH, Genilloud O, Rodríguez-García A, Donadio S, Breitling R, Takano E. “Multi-omics Study of Planobispora rosea, Producer of the Thiopeptide Antibiotic GE2270A”. mSystems. 2021 Jun 29;6(3):e0034121.