Prof. Dr. Stanislav Gobec

Head of Department of Pharmaceutical Chemistry at the University of Ljubljana

I come from a small town in eastern Slovenia. When I was 19 years old, I moved to Ljubljana to study pharmacy. I stayed at the University of Ljubljana, Faculty of Pharmacy, because I was amazed by medicinal chemistry. I find it fascinating to design, synthesise and pharmacologically evaluate compounds that can later become drugs. Is there a better way to contribute to humanity?

Stanislav Gobec studied pharmacy at the Faculty of Pharmacy, University of Ljubljana, where he obtained a Ph.D. in 1999. He has been a full professor of pharmaceutical chemistry at the Faculty of Pharmacy, University of Ljubljana since 2010. His research interests are structure-based in-silico design, synthesis and evaluation of small-molecule enzyme inhibitors for different therapeutic areas, including infectious diseases, cancer and neurodegenerative diseases. He has authored more than 250 papers and book chapters, six granted international patents and has been involved in academic and industrial EU-funded drug discovery and development programs.

  • JUKIČ, Marko, AUGER, Rodolphe, FOLCHER, Victor, PROJ, Matic, BARRETEAU, Hélène, GOBEC, Stanislav, TOUZÉ, Thierry. Towards discovery of inhibitors of the undecaprenyl-pyrophosphate phosphatase BacA by virtual high-throughput screening. Computational and Structural Biotechnology Journal. 2022, 20, 2360–2371. DOI: 10.1016/j.csbj.2022.05.010.


  • GRABRIJAN, Katarina, HRAST, Martina, PROJ, Matic, DOLŠAK, Ana, ZDOVC, Irena, IMRE, Tímea, PETRI, László, ÁBRÁNYI-BALOGH, Péter, KESERÜ M., György, GOBEC, Stanislav. Covalent inhibitors of bacterial peptidoglycan biosynthesis enzyme MurA with chloroacetamide warhead. European Journal of Medicinal Chemistry. 2022, 243, DOI: 10.1016/j.ejmech.2022.114752.


  • DECUYPER, Lena, MAGDALENIĆ, Katarina, VERSTRAETE, Marie, JUKIČ, Marko, SOSIČ, Izidor, SAUVAGE, Eric, AMOROSO, Ana, VERLAINE, Olivier, JORIS, Bernard, GOBEC, Stanislav, D’HOOGHE, Matthias. Alfa-unsaturated 3-amino-1-carboxymethyl-β-lactams as bacterial PBP inhibitors: synthesis and biochemical assessment. Chemistry: A European Journal. 2019, 25, 16128-16140. DOI: 10.1002/chem.201904139.


  • BRÁNYI-BALOGH, Péter, PETRI, László, IMRE, Tímea, SZIJJ, Péter, SCARPINO, Andrea, HRAST, Martina, MITROVIĆ, Ana, PEČAR FONOVIĆ, Urša, NÉMETH, Kristina, BARRETEAU, Hélène, ROPER, David I., HORVÁTI, Kata, FERENCZY, György G., KOS, Janko, ILAŠ, Janez, GOBEC, Stanislav, KESERÜ M., György. A road map for prioritizing warheads for cysteine targeting covalent inhibitors. European Journal of Medicinal Chemistry. 2018, 160, 94-107. DOI: 10.1016/j.ejmech.2018.10.010


  • ŠINK, Roman, SOSIČ, Izidor, ŽIVEC, Matej, FERNANDEZ-MENENDEZ, Raquel, TURK, Samo, PAJK, Stane, ALVAREZ-GOMEZ, Daniel, LOPEZ-ROMAN, Eva Maria, GONZALEZ CORTES, Carolina, RULLAS-TRINCADO, Joaquin, ANGULO-BARTUREN, Iñigo, BARROS, David, BALLELL PAGES, Lluís, YOUNG, Robert J., ENCINAS, Lourdes, GOBEC, Stanislav. Design, synthesis and evaluation of new thiadiazole-based direct inhibitors of enoyl acyl carrier protein reductase (InhA) for the treatment of tuberculosis. Journal of Medicinal Chemistry. 2015, 58, 613-624. DOI: 10.1021/jm501029r.